4/10/2023 0 Comments Ruth posterinoSome people were born with a silver spoon in their mouth (a good life), some got a bad life and I got one somewhere in between. I was going through life like most people, thinking your life was just what you got. 15 years later I almost died from alcohol poisoning. At the tender age of 12 I nearly took my own life. For many years it was far from it, very far from it. “Today I have what some people might call a blessed life, but it wasn’t always this way. We step confidently outside our comfort zones and act on our dreams. We communicate from listening and strength. When we know what to think, we’re left with wishing, praying and hoping, but when we understand how to think, we make better choices. Then we will be empowered to take the actions needed to lose weight and get fit. However, if we know how to think, we can choose to lose weight (rather than know we should). If we know we should lose weight and get fit, it’s possible that nothing will change, other than feeling guilty about our lack of action and poor diet. Knowing something and caring enough about it to take action, are two very different things. At school, they teach us what to know (facts and information), not how to think. Until we realise that what we know, is not the same as how we think, and it’s how we think that causes us to act. That’s right obesity and lack of fitness… It makes no sense, does it?! qns appears to be part of the gating current of the T-system calcium channels.It’s not what we know that creates our results, it’s how we think that determines everything we will ever do, experience and achieve.įor example: Everyone knows how to lose weight and get fit (eat less and exercise more), but according to the World Health Organisation cardiovascular diseases are the leading cause of death in the western world. These results point to a close relationship between slow calcium channels, the qns component of the charge movement and DHP binding sites, in both fast- and slow-twitch mammalian muscle. muscles had between about 2 and 3 times more specific DHP binding sites than did soleus muscle. Experiments on the binding of (+)PN200/110 indicated that e.d.l. The movement of qns occurred over a more negative potential range than the change in calcium conductance. The potential dependence of the slow calcium current implied a minimum gating charge of about five or six electronic charges. In contrast to the other dihydropyridines, (-)bay K8644, a calcium channel agonist, did not suppress any asymmetric charge movement. On average, qns was 3.3 times larger in e.d.l. In all muscle types, the total amount of qns in each fibre was linearly related to the size of the calcium current (in the absence of DHP). Another DHP calcium antagonist, (+)PN200/110, was indistinguishable from nifedipine in its effects of suppressing calcium currents and qns. The calcium current and the qns component of the charge movement also were suppressed over the same time course by nifedipine. Half-maximal suppression of both parameters was obtained with about 0.5 microM-nifedipine. The proportion of qns suppressed by various concentrations of nifedipine was linearly related to the associated reduction of the calcium current. In these normally polarized fibres, nifedipine suppressed only part (qns) of the asymmetric charge movement. and soleus fibres, the dihydropyridine (DHP), nifedipine, suppressed the calcium current entirely. The slow calcium current in soleus fibres was about one-third of the size of the current in e.d.l. The Vaseline-gap technique was used to record slow calcium currents and asymmetric charge movement in single fibres of fast-twitch muscles (extensor digitorum longus (e.d.l.) and sternomastoid) and slow-twitch muscles (soleus) from rat and rabbit, at a holding potential of -90 mV.
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